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Colchicine capsules can cause serious side effects or death.

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colchicine is derived from the dried seeds, or bulb, of the autumn crocus meadow saffron plant, a crocus-type flower.

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clinical features of colchicine toxicity has been categorized into three stages 1 .

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if co-administration of colchicine capsules and a p-gp inhibitor is necessary, the dose of colchicine capsules should be adjusted by either reducing the daily dose or reducing the dose frequency, and the patient should be monitored carefully for colchicine toxicity see clinical pharmacology 12 .

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use of colchicine capsules in conjunction with drugs that inhibit both p-gp and cyp3a4 is contraindicated in patients with renal or hepatic impairment see contraindications 4 .
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