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Metoprolol tartrate showed effects on spermatogenesis in male rats at a therapeutic dose level, but had no effect on rates of conception at higher doses in animal fertility studies see carcinogenesis, mutagenesis, impairment of fertility .

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the dose of metoprolol succinate extended-release tablets should not be increased until symptoms of worsening heart failure have been stabilized.

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both formulations were given in a dose range equivalent to 100-400 mg of immediate-release metoprolol per day.

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